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. 2020 Jun 9;10(4):829–851. doi: 10.1016/j.jcmgh.2020.06.001

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Effects of PF-05221304 on markers of inflammation and fibrogenesis in the DEN-induced hepatic inflammation model. (A) PF-05221304 does not alter liver triglycerides relative to vehicle in DEN-treated rats. (B and C) Effect of PF-05221304 administration on (B) CD3 and (C) αSMA immunohistochemistry staining. (D and F) Effect of PF-05221304 administration on (D) ALT levels and (F) liver weights. Representative histology images are shown for CD3 and αSMA immunohistochemistry. n = 10 animals per treatment group. ∗P < .05 relative to vehicle. ACCi, PF-05221304; Veh, vehicle.