. 2020 Sep 18;13(12):100864. doi: 10.1016/j.tranon.2020.100864

Table 3.

Univariate analysis and Cox proportional hazards regression analysis related to OS.

Variable		Univariate analysis			Multivariate analysis
Variable		HR⁶	95%CI^b	P	HR	95%CI	P
Preoperative Child-Pugh stage				0.330
	A	0.401	0.105–1.524	0.180
	B	0.615	0.277–1.367	0.233
	C
Postoperative Child-Pugh stage^b				<0.001			0.001
	A	0.109	0.039–0.301	<0.001	0.023	0.003–0.167	<0.001
	B	0.201	0.086–0.468	<0.001	0.141	0.039–0.507	0.003
	C
Change of Child-Pugh stage^b				0.009			0.027
	Down	0.174	0.057–0.531	0.002	0.542	0.198–0.731	0.011
	Unchanged	0.308	0.115–0.829	0.020	0.645	0.293–0.879	0.036
	Elevated
Change of Child-Pugh score^b	Down	0.198	0.098–0.398	<0.001	0.085	0.018–0.398	0.002
	Unchanged/elevated
Postoperative grading of ascites^b	0/1	0.226	0.115–0.441	<0.001	0.541	0.137–2.130	0.379
	2/3
Response to TIPS^a				<0.001			0.248
	CR	0.120	0.049–0.296	<0.001	1.316	0.205–8.441	0.772
	PR	0.359	0.149–0.868	0.023	2.434	0.623–9.515	0.201
	AR
BCLC classification^a	A/B	0.466	0.212–1.025	0.049	64,709	0.001–79,050	0.910
	C/D
PVTT^a	No	0.353	0.159–0.785	0.011	0.001	0.001–3303	0.914
	Yes
Number of tumors	Single	0.421	0.182–0.971	0.043	0.822	0.225–3.004	0.767
	Multiple
Intrahepatic local treatment^c	Yes	0.302	0.142–0.642	0.002	0.680	0.181–2.558	0.568
	No
AFP^a	<400	0.341	0.174–0.672	0.002	0.277	0.113–0.679	0.005
	≥400
MELD^a	<15	1.701	0.662–4.370	0.270	0.971	0.312–3.024	0.960
	≥15
Age	<60	1.387	0.722–2.666	0.326	1.394	0.606–3.205	0.434
	≥60

The p-value with bold indicates a statistically significant difference.

The response to TIPS: complete response (CR), no clinically detectable ascites with or without diuretics and sodium limitation; partial response (PR), clinically detectable ascites without the requirement for further paracentesis; or absent response (AR), development of large amount of ascites after TIPS; BCLC, Barcelona Clinic Liver Cancer; PVTT, portal vein tumor thrombosis; AFP, alpha fetoprotein; MELD, model of end stage liver disease; IQR, interquartile range; CI. Confidence interval.

At one month after TIPS, the grading of ascites, Child-Pugh stage, and Child-Pugh score were reassessed.

Including transarterial chemoembolization and ablation.