Table 5.
Top 10 significant pathophysiological dysfunctions in each classification experiment
| Diseases or Functions | P Value | Involved Genes |
|---|---|---|
| NF-DCM | ||
| DCM | 4.28E-16 | ASB2, ATP2A2, CKM, CKMT2, COX7A1, DAG1, DES, DSP, MYH6, MYL3, PKP2, RYR2, SYNE2, TNNT2, TPM1, TTN |
| Familial DCM | 3.10E-14 | DES, DSP, MYH6, MYL3, PKP2, RYR2, TNNT2, TPM1, TTN |
| Left ventricular dysfunction | 4.39E-14 | ATP2A2, CKM, CKMT2, DES, DSP, MYH6, MYL3, PKP2, RYR2, TNNT2, TPM1, TTN |
| Primary DCM | 6.66E-14 | DES, DSP, MYH6, MYL3, PKP2, RYR2, SYNE2, TNNT2, TPM1, TTN |
| Enlargement of heart | 6.97E-13 | ASB2, ATP2A2, CKM, CKMT2, COX7A1, DAG1, DES, DSP, MYH6, MYL3, MYL9, PKP2, RYR2, SYNE2, TNNT2, TPM1, TTN |
| Familial left ventricular noncompaction | 8.86E-13 | MYH6, PKP2, RYR2, TNNT2, TPM1, TTN |
| Arrhythmogenic right ventricular dysplasia familial 9 | 1.72E-11 | DES, MYH6, PKP2, RYR2, TTN |
| Arrhythmogenic right ventricular cardiomyopathy | 2.65E-11 | DES, DSP, MYH6, PKP2, RYR2, TTN |
| DCM 1S | 2.95E-11 | DES, DSP, PKP2, TNNT2, TTN |
| Familial arrhythmia | 3.77E-11 | DES, DSP, MYH6, PKP2, RYR2, TNNT2, TPM1, TTN |
| NF-ICM | ||
| Fibrosis of heart | 5.57E-07 | ATP2A2, DES, MYH6, PLA2G2A, POSTN, STAT3, TNNT2, TRDN |
| Hypertrophy of heart | 8.90E-07 | ATP2A2, CKM, DES, MYH14, MYH6, MYL3, POSTN, STAT3, THBS4, TNNT2 |
| Enlargement of heart | 2.55E-06 | ATP2A2, CKM, DES, ERBB2, MYH14, MYH6, MYL3, POSTN, STAT3, SYNE2, THBS4, TNNT2 |
| Primary DCM | 1.91E-05 | DES, MYH6, MYL3, SYNE2, TNNT2 |
| DCM | 2.51E-05 | ATP2A2, CKM, DES, ERBB2, MYH6, MYL3, SYNE2, TNNT2 |
| Arrhythmia | 2.83E-05 | ATP2A2, DES, KCNIP2, MYH6, TNNT2, TRDN, TUBB4B |
| Left ventricular dysfunction | 3.73E-05 | ATP2A2, CKM, DES, MYH6, MYL3, TNNT2 |
| Familial DCM | 4.52E-05 | DES, MYH6, MYL3, TNNT2 |
| Damage of heart | 6.88E-05 | DES, MYH6, POSTN, STAT3 |
| Enlargement of left ventricle | 1.09E-04 | ATP2A2, CKM, DES, MYL3, TNNT2 |
| DCM-ICM | ||
| Cell death of kidney cells | 1.53E-05 | DCN, FOS, LDHA, MCL1, RHOA, SOD1, SOD2, VDAC1 |
| Cell death of kidney cell lines | 4.23E-05 | FOS, LDHA, MCL1, RHOA, SOD1, SOD2, VDAC1 |
| Disorder of coronary artery | 4.29E-05 | FOS, OGDH, PKM, RHOA, SOD1, THBS1, TUBA4A |
| Liver tumor | 1.29E-04 | B2M, C1S, CFL2, COPA, DCN, DYNC1H1, EFEMP1, FOS, GOLGA4, HABP2, KCNlP2, LDHA, MAT2A, MCL1, NFIX, OGDH, PKM, PPIA, PTGFRN, RPL12, RPL5, RPS29, RPS4X, SBDS, SOD1, SOD2, SPARC, THBS1, TIMP2, TUBA4A, VDAC1 |
| Liver cancer | 1.54E-04 | B2M, C1S, CFL2, COPA, DCN, DYNC1H1, EFEMP1, FOS, GOLGA4, HABP2, KCNlP2, LDHA, MAT2A, MCL1, NFIX, OGDH, PKM, PTGFRN, RPL12, RPS29, RPS4X, SOD1, SOD2, SPARC, THBS1, TIMP2, TUBA4A, VDAC1 |
| Inflammation of heart | 2.05E-04 | ARIH2, B2M, PPIA |
| Coronary artery disease | 4.72E-04 | FOS, OGDH, PKM, RHOA, THBS1 |
| Hepatic adenocarcinoma | 6.78E-04 | MCL1, THBS1, TUBA4A |
| Increased levels of albumin | 1.15E-03 | B2M, THBS1 |
| Apoptosis of cardiomyocytes | 2.11E-03 | MCL1, RHOA, SOD2, TIMP2 |
DCM, dilated cardiomyopathy; ICM, ischemic cardiomyopathy; NF, nonfailure controls.