Table 1.

Anthropometric and biochemical measurements of WT and Sulf2-KO mice fed either standard chow or fast food diet

	Standard Chow Diet		Fast-Food Diet
Parameters	WT (n = 11)	Sulf2-KO (n = 12)	WT (n = 12)	Sulf2-KO (n = 11)	P Value*	P Value**
Initial weight, g	22.2 ± 1.1	17.7 ± 0.9	21.5 ± 1.4	17.7 ± 0.7	0.7	0.02
Final weight, g	43.1 ± 3.7	29.1 ± 1.5	65.3 ± 3.3	44.7 ± 4.7	<0.0001	0.0002
Percent weight gain, %	93.1 ± 11.9	65.3 ± 5.5	207.6 ± 13.0	144.7 ± 19.7	<0.0001	0.002
Liver-to-body wt ratio, %	3.2 ± 0.1	3.2 ± 0.2	4.8 ± 0.4	5.6 ± 0.7	0.01	0.2
Adipose-to-body wt ratio, %	4.7 ± 0.4	3.1 ± 0.4	7.3 ± 0.9	7.6 ± 1.1	0.02	0.8
Glucose, mg/dL	144.7 ± 6.2	134.3 ± 5.4	209.7 ± 10.3	182.0 ± 3.6	<0.0001	0.01
Insulin, IU/mL	21.4 ± 4.4	20.2 ± 3.5	74.1 ± 12.7	48.9 ± 12.0	<0.0001	0.06
HOMA-IR, %	7.4 ± 1.4	6.8 ± 1.3	38.2 ± 6.6	22.0 ± 5.4	<0.0001	0.01
GH, ng/mL	5.6 ± 0.2	9.8 ± 0.8	1.8 ± 0.3	5.8 ± 0.6	<0.0001	<0.0001

Data are presented as means ± SE; n, number of mice. GH, growth hormone; HOMA-IR, homeostasis model assessment of insulin resistance.

^*P value of WT mice fed standard chow diet vs. fast-food diet.

^**P value of WT vs. Sulf2-KO mice fed fast-food diet.