Fig. 5.

Mice fed American lifestyle-induced obesity syndrome (ALIOS) diet have increased hepatic inflammation. Histologically determined inflammation scores of male (A) and female (B) normal chow (NC)- and ALIOS-fed mice at 26 wk (w; NC males, n = 12; ALIOS males, n = 15; NC females, n = 15; ALIOS females, n = 15) and 52 wk (NC males, n = 17; ALIOS males, n = 12; NC females, n = 15; ALIOS females, n = 15) are shown. Data are expressed as means ± SE. Both male (C) and female (D) mice had increased hepatic expression of genes involved in inflammation, including macrophage infiltration compared with NC-fed mice at 52 wk. n = 8 Mice in each group; *P < 0.05, ***P < 0.001, ****P < 0.0001.