Table 1.

Circulating serum levels of lipids

	16 wk		25 wk		37 wk		52 wk
	NC	ALIOS	NC	ALIOS	NC	ALIOS	NC	ALIOS
Males, mmol/L
Total cholesterol	2.6 ± 0.1	3.9 ± 0.2‡	2.1 ± 0.1	4.1 ± 0.2§	2.4 ± 0.1	4.6 ± 0.3§	2.5 ± 0.2	5.8 ± 0.4§
HDL	1.8 ± 0.1	2.7 ± 0.1§	1.5 ± 0.1	2.9 ± 0.1§	1.7 ± 0.1	3.1 ± 0.2§	1.7 ± 0.1	3.7 ± 0.4§
LDL	0.59 ± 0.02	0.9 ± 0.1‡	0.43 ± 0.03	0.9 ± 0.1§	0.6 ± 0.1	1.3 ± 0.2§	0.5 ± 0.1	1.8 ± 0.2§
TAG	1.1 ± 0.1	1.2 ± 0.1	1.0 ± 0.1	1.0 ± 0.1	1.3 ± 0.1	1.1 ± 0.1	0.94 ± 0.04	0.67 ± 0.04§
Free fatty acids	1.7 ± 0.1	1.5 ± 0.1	0.9 ± 0.1	0.81 ± 0.05	1.9 ± 0.1	1.8 ± 0.1	0.8 ± 0.1	0.67 ± 0.04*
Females, mmol/L
Total cholesterol	2.0 ± 0.1	2.4 ± 0.2*	2.0 ± 0.1	2.8 ± 0.2‡	1.7 ± 0.1	2.9 ± 0.2‡	1.7 ± 0.1	3.2 ± 0.4‡
HDL	1.3 ± 0.1	1.5 ± 0.1	1.4 ± 0.1	2.0 ± 0.1‡	1.2 ± 0.1	2.1 ± 0.1‡	1.2 ± 0.1	2.1 ± 0.2‡
LDL	0.48 ± 0.03	0.57 ± 0.04	0.45 ± 0.02	0.61 ± 0.04‡	0.43 ± 0.01	0.71 ± 0.08†	0.36 ± 0.02	0.74 ± 0.13‡
TAG	0.8 ± 0.1	1.0 ± 0.1	0.65 ± 0.03	0.55 ± 0.02*	0.97 ± 0.02	0.71 ± 0.04‡	0.81 ± 0.03	0.55 ± 0.03†
Free fatty acids	1.7 ± 0.1	1.7 ± 0.1	0.81 ± 0.04	0.64 ± 0.04†	1.95 ± 0.15	1.37 ± 0.07‡	0.97 ± 0.06	0.69 ± 0.04†

Values are means ± SE. n = 12–15 Mice in each group. ALIOS, American lifestyle-induced obesity syndrome; TAG, triacylglycerol. Significantly different from normal chow (NC) at same age,

^*P < 0.05,

^†P < 0.01,

^‡P < 0.001, and

^§P < 0.0001.