Table 1.

Physiological parameters in control and inhibitor-treated Tally-Ho/Jng mice

	Control	Inhibitor	P Value
Body weight, g	48.1 ± 1.7	43.9 ± 2.2	0.16
Heart weight, g	0.201 ± 0.006	0.208 ± 0.008	0.53
Heart weight, g/40 g body wt	0.168 ± 0.004	0.192 ± 0.012	0.064
Glucose, mmol/L	14.4 ± 2.1	13.0 ± 1.3	0.60
Na+, mmol/L	144 ± 1	147 ± 1	0.007*
Urine volume, ml/24 h†	0.44 ± 0.07	0.50 ± 0.08	0.57
K+, mmol/L	4.86 ± 0.19	4.89 ± 0.14	0.92
Cl−, mmol/L	118 ± 1	118 ± 1	0.95
Blood urea nitrogen, mg/dL	22.1 ± 0.9	18.6 ± 0.6	0.006*
BEecf, mmol/L	3.75 ± 1.93	−1.25 ± 1.51	0.06
Hct, %PCV	29.3 ± 1.6	30.6 ± 1.09	0.48
${\text{HCO}}_3^{-}$, mmol/L	30.6 ± 1.5	26.7 ± 1.2	0.07
AnGap, mmol/L	0.75 ± 1.93	8.00 ± 1.77	0.015*
Hb, g/dL	9.94 ± 0.53	10.4 ± 0.4	0.47
pH, −log[H+]	7.27 ± 0.03	7.21 ± 0.02	0.09

Data are means ± SE; n = 8 mice/treatment. BEecf, base excess in extracellular fluid; Hct, hematocrit; PCV, packed cell volume; AnGap, anion gap; Hb, hemoglobin.

^*Significantly different as determined by an unpaired t test.

^†Final collection.