Comparison of solute delivery (A–C) and fluid delivery (D) obtained for the base case and for 70% and 100% sequential nephron blockade (SNB; simultaneous inhibition of Na+-K+-2Cl− cotransporter, Na+-Cl− cotransporter, and epithelial Na+ channel). Colored bars show superficial nephron values; white bars show juxtamedullary values. Delivery values are computed per kidney. PT, proximal tubule; DL, descending limb; TAL, thick ascending limb; DCT, distal convoluted tubule; CNT, connecting tubule; CCD, cortical collecting duct; TA, titratable acid.