Table 1.
Metabolic data for male and female spontaneously hypertensive rats with and without IL-10 treatment
| Male |
Female |
Two-Way ANOVA P Values |
|||
|---|---|---|---|---|---|
| Control (n = 4) |
IL-10 (n = 6) |
Control (n = 6) |
IL-10 (n = 6) |
||
| Baseline | |||||
| Body weight, g | 288.50 ± 6.62 | 289.67 ± 5.21 | 179.83 ± 4.67 | 181.00 ± 6.78 | Interaction: P > 0.99 Treatment: P = 0.84 Sex: P < 0.01* |
| Water intake, mL | 33.67 ± 2.97 | 33.05 ± 1.52 | 37.18 ± 7.07 | 26.98 ± 2.86 | Interaction: P = 0.26 Treatment: P = 0.21 Sex: P = 0.76 |
| Food intake, g | 20.08 ± 2.42 | 19.03 ± 1.44 | 11.58 ± 0.93 | 10.28 ± 0.81 | Interaction: P = 0.94 Treatment: P = 0.45 Sex: P < 0.01* |
| Urine output, mL | 14.93 ± 0.92 | 14.10 ± 1.05 | 8.60 ± 2.25 | 9.85 ± 1.42 | Interaction: P = 0.50 Treatment: P = 0.89 Sex: P < 0.01* |
| After 1 wk of treatment | |||||
| Body weight, g | 299.5 ± 6.82 | 301.25 ± 4.34 | 187.42 ± 5.05 | 183.83 ± 4.04 | Interaction: P = 0.61 Treatment: P = 0.86 Sex: P < 0.01* |
| Water intake, mL | 53.97 ± 2.54 | 52.73 ± 4.44 | 45.27 ± 3.11 | 39.7 ± 3.37 | Interaction: P = 0.54 Treatment: P = 0.33 Sex: P < 0.01* |
| Food intake, g | 27.48 ± 1.18 | 24.67 ± 1.36 | 17.42 ± 1.26 | 18.28 ± 1.72 | Interaction: P = 0.20 Treatment: P = 0.49 Sex: P < 0.01* |
| Urine output, mL | 25.68 ± 2.74 | 27.70 ± 3.53 | 17.82 ± 1.94 | 15.30 ± 1.21 | Interaction: P = 0.38 Treatment: P = 0.92 Sex: P < 0.01* |
| After 2 wk of treatment | |||||
| Body weight, g | 321.25 ± 8.21 | 311.50 ± 5.40 | 188.67 ± 4.31 | 187.33 ± 4.72 | Interaction: P = 0.48 Treatment: P = 0.36 Sex: P < 0.01* |
| Water intake, mL | 46.40 ± 6.98 | 45.32 ± 4.83 | 41.70 ± 3.82 | 33.28 ± 3.87 | Interaction: P = 0.48 Treatment: P = 0.36 Sex: P = 0.12 |
| Food intake, g | 25.45 ± 1.05 | 24.73 ± 0.80 | 17.57 ± 1.52 | 16.78 ± 1.26 | Interaction: P = 0.98 Treatment: P = 0.56 Sex: P < 0.01* |
| Urine output, mL | 16.25 ± 1.87 | 16.33 ± 2.57 | 15.42 ± 2.33 | 14.62 ± 1.56 | Interaction: P = 0.85 Treatment: P = 0.88 Sex: P = 0.58 |
Values are means ± SE. Metabolic data at baseline, after 1 wk of treatment, and after 2 wk of treatment in male and female control and interleukin-10 (IL-10)-treated spontaneously hypertensive rats are shown. Rats were placed in metabolic cages for 24 h at three time points to collect metabolic data, including body weight, water intake, food intake, and urine output. Data were analyzed by two-way ANOVA at each time point and are presented as the effect of treatment, effect of sex, and interaction of sex and treatment.
*
P < 0.05.