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. 2020 Sep 4;10:1706. doi: 10.3389/fonc.2020.01706

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Copyright © 2020 Chen, Li, Liu, Chen, Xu, Song and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relationship between blood mutational landscape and therapeutic response. (A) The pre-therapeutic blood ctDNA mutational landscape. (B) Keplan–Meier survival analysis of patients with negative or positive ctDNA mutation detection (left panel, 7 patients with negative and 15 patients with positive ctDNA mutation detection) or patients with low or high bTMB levels (right panel, 8 patients with high and 14 patients with low bTMB levels). (C) Correlation between cfDNA concentration and PFS (left panel) or bTMB (right panel).