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. 2020 Sep 8;8:565020. doi: 10.3389/fcell.2020.565020

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Copyright © 2020 Sun, Jiang, Zhang, Li, Tian and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prickle2 is downregulated in the brain tissues of 3 × Tg mice. (A) Prickle2 mRNA (n = 6 per group) in the cortex and the hippocampus isolated from mouse brain. (B) Western blotting for Prickle2 in the cortex and the hippocampus isolated from mouse brain (n = 6 per group). (C) IHC for Prickle2 in cortex and hippocampus isolated from mouse brain (n = 6 per group). (D) Western blots in cell lysates from AD mice during aging with antibodies against Prickle2 and GAPDH, as indicated. Blotting intensities are normalized to GAPDH from AD mice at three months old of age (defined as 1.0, n = 6) (A–D) Student’s t test. ^∗∗p < 0.01; ^∗∗∗p < 0.001; ^*⁣*⁣**p < 0.0001.