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. 2020 Sep 8;8:565020. doi: 10.3389/fcell.2020.565020

FIGURE 2.

FIGURE 2

AAV-mediated Prickle2 overexpression ameliorates impaired learning and memory in 3 × Tg mice. (A) Experimental schedule for AAV-PHP.eB-mediated Prickle2 treatment. (B) Evaluation of the infection efficiency after injection of AAV-PHP.eB virus. Immunofluorescence analysis showing the expression of mScarlet in the brain coronal sections. (C) Escape latency plotted according to the training days. (D) Typical swimming traces during the escape latency process through MWM test on day 5. (E) Frequency passed the hidden platform and (F) original angle data plotted during the MWM test on day 6. (G) The swim velocity and length (H) was calculated, and there was no significant group difference in average swim velocity or length. (I) Typical spatial probe process during the MWM test on day 6. All experiments were performed on 7-month-old mice (n = 12). ANOVA followed by Bonferroni’s post hoc test. ∗p < 0.05; ∗∗p < 0.01; ns, not significant.