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. 2020 Sep 8;8:565020. doi: 10.3389/fcell.2020.565020

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Copyright © 2020 Sun, Jiang, Zhang, Li, Tian and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prickle2 overexpression ameliorates oxidative stress and neuroinflammation in 3 × Tg mice. (A) The level of MDA and (B) the activity of SOD was determined in the brain of WT, 3 × Tg and 3 × Tg/Prickle2 treatment mice (n = 6 per group). (C) The ROS level was measured in the supernatants of the brain homogenates of WT, 3 × Tg and 3 × Tg/Prickle2 treatment mice (n = 6 per group). (D) The levels of IL-1β and (E) IL-6 were determined by ELISA in the brain of WT, 3 × Tg and 3 × Tg/Prickle2 treatment mice (n = 6 per group). (F) Brain sections of the cortex and hippocampus were stained with anti-Iba1 and anti-Aβ4G8 antibodies. (A–E) ANOVA followed by Bonferroni’s post hoc test. ^∗p < 0.05; ^∗∗p < 0.01.