FIGURE 4.

Prickle2 treatment diminishes Aβ deposition and Aβ levels in 3 × TG mice. (A) Representative thioflavin S (ThioS, Aβ plaques) immunofluorescence images in cortex and hippocampus of WT, 3 × Tg and 3 × Tg/Prickle2 treatment mice. The percentage of cortical and hippocampal area occupied by Aβ plaques (n = 6 per group). (B) Representative images of WT, 3 × Tg and 3 × Tg/Prickle2 treatment mice stained with X-34 and the percentage of cortical and hippocampal area stained with X-34 was quantified (n = 6 per group). (C) Representative immunofluorescence images stained byβ-Amyloid 4G8 antibody. The percentage of cortical and hippocampal area stained withβ-Amyloid 4G8 antibody was quantified (n = 6 per group). ANOVA followed by Bonferroni’s post hoc test. ^∗∗p < 0.01; ^∗∗∗p < 0.001.