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. 2020 Sep 4;11:1775. doi: 10.3389/fimmu.2020.01775

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Copyright © 2020 Vardi, Chermesh, Werner, Barel, Freund, McCourt, Fisher, Pinsker, Javasky, Weiss, Rechavi, Hagin, Snapper, Somech, Konnikova and Shouval.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The LRBA-deficient patient exhibits significantly altered immune landscape. (A) Main immune subtypes as a proportion of total leukocytes in control and patient samples. (B) tSNE map generated after Phenograph clustering of all samples combined. Top row: cluster map. Bottom row: density plots. (C) Ratio of CD4⁺ to CD8⁺ T cells and (D) ratio of naïve:memory T cells in control and patient samples. (E) Tregs as percent of total leukocytes. (F) Mean metal intensity (MMI) of FOXP3, CD25, and IL-10 in patient and control Tregs. ***P < 0.001. CM, central memory; DC, dendritic cells; DNT, double negative T cells; EM, effector memory; ILC, innate lymphoid cells; MDCS, myeloid derived suppressor cells; Mono, monocytes; n, naïve; NKT, natural killer T cells; Tregs, regulatory T cells.