Fig. 7.

Effects of high folic acid supplementation on the S-adenosylmethionine and S-adenosylhomocysteine content of C. elegans.S-adenosylmethionine (SAM, A) and S-adenosylhomocysteine (SAH, B) were determined in high-dose folic acid (FA)-supplemented and control worms using HPLC, followed by the calculation of the SAM/SAH ratio (C). Data are presented as the mean ± SEM of three independent experiments. Different letters (a, b) indicate values that are significantly different (P < 0.05); identical letters indicate values that are not significantly different. ns, non-significant difference vs. the control.