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. 2020 Sep 18;13:9269–9280. doi: 10.2147/OTT.S255644

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© 2020 Zhang et al.

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Rab14 promotes cell proliferation. (A) pCMV6-Rab14 transfection upregulated Rab14 protein level significantly in LK2 cells while siRNA transfection downregulated Rab14 protein levels in both A549 and H1299 cells. (B) Rab14 mRNA levels increased in LK2 cells transfected with Rab14 plasmid. In A549 and H1299 cells, Rab14 mRNA levels decreased after siRNA transfection. (C) MTT results showed that proliferation rate increased after pCMV6-Rab14 transfection in LK2 cells, while Rab14 depletion inhibited proliferation rate in A549 and H1299 cells. Experiments were performed in triplicate *p<0.05.