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. 2020 Sep 18;13:9269–9280. doi: 10.2147/OTT.S255644

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© 2020 Zhang et al.

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Rab14 regulates cell cycle and related protein. (A) Flow cytometry results showed that Rab14 transfection decreased G1 phase percentage and increased S phase percentage in LK2 cells. Rab14 siRNA increased G1 phase percentage and decreased S phase percentage in A549 and H1299 cells. (B) Rab14 overexpression upregulated Rab14, Cyclin E, cyclin D1, CTGF protein levels while downregulating p27 level in LK2 cells. Rab14 depletion downregulated Rab14, cyclin E, cyclin D1, CTGF while upregulating p27 protein levels in A549 and H1299 cells. (C) Rab14, Cyclin D1, cyclin E, CTGF mRNA levels increased while p27 level decreased in LK2 cells transfected with Rab14 plasmid. Rab14 depletion decreased Rab14, cyclin D1, cyclin E, CTGF while increased p27 mRNA levels in both A549 and H1299 cells. Experiments were performed in triplicate *p<0.05.