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. 2020 Sep 18;13:9269–9280. doi: 10.2147/OTT.S255644

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© 2020 Zhang et al.

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Rab14 regulates cyclin D1, cyclin E and CTGF through YAP. (A) Lung cancer cells were transfected with pCMV6-Rab14/Rab14 siRNA, and then treated with cycloheximide (CHX) for 0, 4, 6 hours respectively. Western blot results showed that Rab14 depletion accelerated YAP degradation in A549 and H1299 cells while Rab14 overexpression decreased YAP degradation in LK2 cells. (B) YAP siRNA was used in cells transfected with Rab14 plasmid and siRNA. YAP siRNA significantly decreased expression of cyclin D1, cyclin E and CTGF. In cells transfected with YAP siRNA, the effect of Rab14 plasmid/siRNA on cyclin D1, cyclin E and CTGF protein was significantly ameliorated.