Table 2.
Changes in Liver Concentration of Pro- and Anti-Inflammatory Cytokines Related to Pathophysiology of NASH
| Variable # | Control (n=10) | Intervention (n=10) | p * |
|---|---|---|---|
| TNF-α (pg/mg) | 9720.3 (± 3048.0) | 13,904.3 (± 3231.5) | 0.008 |
| IL-1β (pg/mg) | 2186.0 (± 302.9) | 2934.3 (± 456.0) | 0.001 |
| IL-6 (pg/mg) | 50,378.5 (± 8347.8) | 49,175.3 (± 7329.2) | 0.736 |
| IL-10 (pg/mg) | 7116.8 (± 1158.4) | 5125.9 (± 781.0) | < 0.001 |
| TNF-α/IL-10 ratio | 1.4 (± 0.6) | 2.8 (± 1.0) | 0.001 |
| IL-1β/IL-10 ratio | 0.3 (± 0.1) | 0.6 (± 0.1) | < 0.001 |
| IL-6/IL-10 ratio | 7.2 (± 1.3) | 9.7 (± 1.7) | 0.002 |
Notes: #Variables described as mean ± standard deviation; *Student’s t-test, p < 0.05 considered significant.
Abbreviations: IL, interleukin; NASH, non-alcoholic steatohepatitis; TNF, tumor necrosis factor.