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. 2020 Sep 18;13:351–368. doi: 10.2147/CEG.S262879

Table 3.

Gene Expression of Gut Permeability Markers and Hepatic Inflammation Involved in NASH Pathogenesis

Variables # Control (n=10) Intervention (n=10) p *
Evaluation performed on intestinal tissue
Ocln 0.87 (0.6–1.8) 0.29 (0.1–0.5) 0.003
F11r (JAM-1) 1.5 (0.5–2.7) 0.3 (0.2–0.6) 0.041
Cldn1 1.1 (0.3–1.8) 2.7 (1.2–3.3) 0.495
Cldn4 1.4 (0.6–1.6) 0.8 (0.5–2.2) 0.657
Evaluation performed on liver tissue
Tlr4 17.3 (0.2–9.0) 50.5 (2.2–40.7) 0.041
Tlr9 13.3 (11.6–15.1) 14.8 (14.5–18.3) 0.033
Tlr2 1.3 (0.5–2.0) 1.0 (0.1–1.8) 0.364
Myd88 1.6 (0.4–2.4) 5.1 (2.9–7.7) < 0.001
Nlrp3 3.9 (1.4–4.2) 13.8 (3.8–20.5) 0.019
Casp1 2.1 (0.2–3.1) 82.3 (10.1–148.0) < 0.001
Tnfa 17.3 (0.3–1.6) 111.4 (1.0–193.2) 0.028
Il6 1.2 (0.6–1.7) 9.8 (1.3–6.2) 0.013
Il18 2.2 (0.4–3.2) 14.9 (2.0–25.0) 0.007
Il1b 1.2 (0.7–1.7) 2.5 (1.1–3.9) 0.082
Il10 1.3 (0.6–1.7) 1.4 (0.6–2.1) 0.940
Ppara 1.4 (0.5–2.2) 0.4 (0.1–0.4) 0.008

Notes: #Variables described as median (25th - 75th percentiles) *Mann–Whitney U-test, p < 0.05 considered significant. β-actin gene was used as a housekeeping gene.

Abbreviations: Casp-1, caspase-1; Cldn, claudin; IL, interleukin; Jam, junctional adhesion molecule; MyD-88, myeloid differentiation primary response-88; NASH, non-alcoholic steatohepatitis; NLRP-3, Nod-like receptor protein-3; Ocln, occludin; PPAR, peroxisome proliferator-activated receptor; TLR, toll-like receptor; TNF, tumor necrosis factor.