Table 5.
Correlations Between NASH Markers and Microbiota Composition
| Variables # | Inflammatory Response | Intestinal Permeability | Microbiota Composition | ||
|---|---|---|---|---|---|
| Index TNF-α/IL-10 (pg/mg) |
Index IL-1β/IL-10 (pg/mg) |
Ocln | F11r (JAM-1) | ||
| NAFLD scoring | 0.751** | 0.832** | −.719** | −.525* | 0.694** |
| Index TNF-α/IL-10 (pg/mg) | 0.729** | −.463* | −.208 | 0.234* | |
| Index IL-1β/IL-10 (pg/mg) | −.457* | −.361 | 0.522* | ||
| Ocln | 0.722** | 0.090 | |||
| F11r (JAM-1) | 0.146* | ||||
Notes: #Variables was represented for Spearman correlation coefficient. Moderate (0.3 < r < 0.6 - blue) and strong (0.6 < r < 0.9 - green) correlation of Spearman’s. ** Correlation is significant at the 0.01 level. * Correlation is significant at the 0.05 level.
Abbreviations: IL, interleukin; JAM, junctional adhesion molecule; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; Ocln, occludin; TNF, tumor necrosis factor.