Table 1.
Use of respiratory interventions in COVID-19 patient population
| Study | Huang et al. [5] (n = 41) |
Wu et al. [6] (n = 201) | Wang et al. [7] (n = 138) |
Guan et al. [8] (n = 1099) |
Yang et al. [9] (n = 52) |
Arentz et al. [10] (n = 21) |
Grasseli et al. [11] (n = 1591) |
Richardson et al. [12] (n = 5700) |
|---|---|---|---|---|---|---|---|---|
| Study design | Prospective cohort, single center | Retrospective cohort, single center | Retrospective, single-center case series | Retrospective data from 552 hospitals in China | Retrospective cohort, single center | Retrospective cohort, single center | Retrospective case series | Retrospective case series |
| Study population | Confirmed COVID-19 cases from Dec 16, 2019, to Jan 2, 2020 | Confirmed COVID-19 cases from Dec 25, 2019, to Jan 26, 2020 | Confirmed COVID-19 cases from Jan 1 to Jan 28, 2020 | Confirmed COVID-19 cases through January 29, 2020 | Critically illb confirmed COVID-19 cases from late Dec 2019 to Jan 26, 2020 | Confirmed COVID-19 cases admitted to ICU from Feb 20 to March 5, 2020 | Critically ill laboratory-confirmed COVID-19 cases from Feb 20 to March 18, 2020 | Confirmed COVID-19 cases admitted to 12 hospitals in New York City from March 1 to April 4, 2020 |
| Age | 49 (IQR, 41–58) | 51 (IQR, 43–60) | 56 (IQR, 42–68) | 47 (IQR 35–58) | 59.7 (± 13.3) | 70 (IQR, 43–92) | 63 (IQR, 56–70) | 63 (IQR, 52–75) |
| ICU admission | 13 (32%) | 53 (26.4%) | 36 (26%) | 55 (5%) | 52 (100%) | 21 (100%) | 1591 (100%) | 373/2634 (14.2%) |
| Acute respiratory distress syndrome | 12 (29%) | 84 (41.8%) | 27 (19.6%) | 37 (3.4%) | 35 (67%) | 20 (95%) | NR | NR |
| Oxygen therapy | 27 (66%) | 98 (49%) | 106 (77%) | 454 (41.3%) | NR | NR | 13/1300 (1%) | 1584/5693 (27.8%) |
| High-flow nasal cannula | 10 (24%)a | NR | NR | NR | 33 (63.5%) | 1 (4.8%) | NR | NR |
| Non-invasive ventilation | 10 (24%)a | 61 (30%) | 15 (10.9%) | 56 (5.1%) | 29 (56%) | 4 (19%) | 137/1300 (11%) | NR |
| Invasive mechanical ventilation | 2 (5%) | 5 (2.5%) | 17 (12.3%) | 25 (2.3%) | 22 (42%) | 15 (71%) | 1150/1300 (88%) | 320/2634 (12.2%) |
| Prone position ventilation | NR | NR | NR | NR | 6 (11.5%) | 8 (38%) | 240/875 (27%) | NR |
| ECMO | 2 (5%) | 1 (0.5%) | 4 (2.9%) | 5 (0.5%) | 6 (11.5%) | NR | 5/498 (1%) | NR |
Abbreviations: ICU intensive care unit, IMV invasive mechanical ventilation, ECMO extracorporeal membrane oxygenation, NR not reported
aReported as NIV or HFNC use; bdefined as those admitted to ICU requiring mechanical ventilation or had FiO2 ≥ 0.6