Table 1.
Clinicopathological characteristics of 285 patients and immunohistochemical staining for MMP-7 and TIMP-1.
| Variables | N (%) | MMP-7 | TIMP-1 | |||
|---|---|---|---|---|---|---|
| + (%) | P | + (%) | P | |||
| Sex | 0.02 | 0.06 | ||||
| Male | 219 (76.8) | 83 (37.9) | 54 (24.7) | |||
| Female | 66 (23.2) | 15 (22.7) | 24 (36.4) | |||
|
| ||||||
| Age | 0.55 | 0.37 | ||||
| <70 | 212 (74.4) | 75 (35.4) | 61 (28.8) | |||
| ≥70 | 73 (25.6) | 23 (31.5) | 17 (23.3) | |||
|
| ||||||
| T stage | 0.71 | 0.67 | ||||
| T1 | 4 (1.4) | 1 (25.0) | 1 (25.0) | |||
| T2 | 10 (3.5) | 2 (20.0) | 1 (10.0) | |||
| T3 | 148 (51.9) | 49 (33.1) | 40 (27.0) | |||
| T4 | 123 (43.2) | 46 (37.4) | 36 (29.3) | |||
|
| ||||||
| N stage | 0.03 | 0.67 | ||||
| N0 | 47 (16.5) | 8 (17.0) | 11 (23.4) | |||
| N1 | 48 (16.8) | 16 (33.3) | 13 (27.1) | |||
| N2 | 77 (27) | 33 (42.9) | 25 (32.5) | |||
| N3 | 113 (39.6) | 41 (36.3) | 29 (25.7) | |||
|
| ||||||
| Differentiation | 0.74 | 0.48 | ||||
| Middle | 58 (20.4) | 21 (36.2) | 18 (31.0) | |||
| Low | 227 (79.6) | 77 (33.9) | 60 (26.4) | |||
|
| ||||||
| Type | 0.59 | 0.73 | ||||
| Adenocarcinoma and others | 255 (89.5) | 89 (34.9) | 69 (27.4) | |||
| Signet-ring cell | 30 (10.5) | 9 (30.0) | 9 (30.0) | |||
|
| ||||||
| Size | 0.30 | 0.61 | ||||
| <5 cm | 85 (29.8) | 33 (38.8) | 25 (29.4) | |||
| ≥5 cm | 200 (70.2) | 65 (32.5) | 53 (26.5) | |||
|
| ||||||
| Lymph vascular invasion | 0.76 | 0.63 | ||||
| No | 64 (22.5) | 21 (32.8) | 16 (25.0) | |||
| Yes | 221 (77.5) | 77 (34.8) | 62 (28.1) | |||
|
| ||||||
| Neural invasion | 0.002 | 0.11 | ||||
| No | 78 (27.4) | 16 (20.5) | 16 (20.5) | |||
| Yes | 207 (72.6) | 82 (39.6) | 62 (30.0) | |||
|
| ||||||
| Chemotherapy | 0.13 | 0.07 | ||||
| No | 160 (56.1) | 61 (38.1) | 37 (23.1) | |||
| Yes | 125 (43.9) | 37 (29.6) | 41 (32.8) | |||
+: positive expression.