Figure 2.

Magnesium silicide nanoparticles as a deoxygenation agent for inhibiting mitochondrial respiration of cancer cells. a) Transmission electron microscopy (TEM) image of highly dispersed Mg₂Si nanoparticles. Scale bar, 500 nm. b) High‐resolution TEM image showing the serrated edge of a single Mg₂Si nanoparticle. Scale bar, 5 nm. c) Mechanism of deoxygenation reaction by Mg₂Si nanoparticles. d) Bio‐TEM images of MCF‐7 cells treated with Mg₂Si nanoparticles for prolonged durations, which show morphological damage of suffocated mitochondria. e) ¹⁸F‐labeled fluoromisonidazole positron emission tomography (PET)/computed tomography (CT) images before and after different‐treatments showing a significantly enhanced hypoxia after Mg₂Si nanoparticle (denoted MS NP in this figure) injection. Reproduced with permission.^{[ 10 ]} Copyright 2017, the Authors, published by Springer Nature.