Figure 14.

Combination of glutaminolysis and glucose metabolism inhibitions for pancreatic cancer treatment. a) Component of the designed nanoparticle encapsulating the glutaminolysis inhibitor bis‐2‐(5‐phenylacetamido‐1,2,4‐thiadiazol‐2‐yl)ethyl sulfide (BPTES). b) TEM image of the BPTES nanoparticles. c–e) Metabolomics analysis of c) glutamine, d) glucose, and e) lactate of tumors harvested from mice treated with BPTES nanoparticles. Reproduced with permission.^{[ 50 ]} Copyright 2016, National Academy of Sciences.