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Organoiridium catalysts regulate celluar NAD+/NADH ratio for sensitizing cancer cells to chemodrugs. a) Organoiridium catalyst‐triggered chemical reactions lead to increased chemosensitivity of cancer cells toward platinum drugs. b,c) [NAD+]/[NADH] ratio change in Y79 (eye/retina cancer) and A549 (lung cancer) cells upon treatment with carboplatin (denoted DCP), complex 1 (denoted 1), or both. Reproduced with permission.[ 60 ] Copyright 2017, Wiley‐VCH.
