Table 3.
Meta-analysis of the association between high Ki-67 expression and clinicopathological features of NPC.
| Variables | No. of studies | OR (95% CI) | p | Heterogeneity | Effects model | |
|---|---|---|---|---|---|---|
| I2 (%) | Ph | |||||
| Gender (male versus female) | 5 | 1.01 (0.71–1.44) | 0.963 | 31.8 | 0.209 | Fixed |
| Age (years) (⩾45 versus <45) | 4 | 1.10 (0.68–1.77) | 0.699 | 0 | 0.599 | Fixed |
| Clinical stage (III+IV versus I+II) | 4 | 2.25 (0.99–5.14) | 0.054 | 53.9 | 0.089 | Random |
| T stage (T3+T4 versus T1+T2) | 4 | 1.48 (1.00–2.20) | 0.052 | 0 | 0.954 | Fixed |
| N stage (N2+N3 versus N0+N1) | 4 | 1.73 (0.71–4.24) | 0.231 | 76.7 | 0.005 | Random |
| Histological type (undifferentiated versus keratinizing/non-keratinizing) | 2 | 0.74 (0.40–1.32) | 0.295 | 48.4 | 0.164 | Fixed |
CI, confidence interval; NPC, nasopharyngeal carcinoma; OR, odds ratio.