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. 2020 Aug 4;7(18):2000906. doi: 10.1002/advs.202000906

Figure 4.

Figure 4

PA/PI‐ND improved immunotherapy efficiency and could reverse the immunosuppressive tumor microenvironment through the repolarization of M2 TAMs and decrease Treg cells. a) The number of M1 and M2 macrophages in RAW 264.7 cells (**p < 0.01). b) Ratio of M1 to M2 after treatment with different samples (*p < 0.05, **p < 0.01, ***p < 0.001, compared with PA/PI‐ND group; #p < 0.05, ###p < 0.001, compared with abemaciclib and IMD‐0354 mixture group). c) Numbers of M1 and M2 TAMs. d) Ratio of M1 to M2 TAMs in tumor tissues (*p < 0.05, **p < 0.01, compared with PA/PI‐ND group). e) Percentage of Treg cells in tumor tissues after treatment with different formulations. f–j) Cytokine levels in peripheral blood (n = 3, *p < 0.05, **p < 0.01, compared with PA/PI‐ND group).