Scheme 1.

Schematic illustration of pH‐triggered dual charge and size responsive nanocage for novel triple‐interlocked combination therapy. a) Preparation of PA/PI‐ND; b) Delivery of PA/PI‐ND; i) PA/PI‐ND delivery to tumor tissues by the NGR ligand. ii) PA/PI‐ND gradually became positively charged and disintegrated, releasing PA and PI under conditions mimicking the acidic tumor microenvironment. iii) PA and PI reached the tumor interstitial region achieving deep tumor penetration. c) PA/PI‐ND exhibited a triple‐interlocked combination improving the therapeutic effect of chemotherapy, immunotherapy, and chemoimmunotherapy.