Table 1.

List of main SPECT radiotracers for SLN detection in patients with melanoma.

Class of Tracer	Radiotracer	Listed Trade Names	Particle Size (nm)	Additional Notes
Radiolabelled colloids	¹⁹⁸Au-Colloid	N/A	9-15	β-emitter and unfavorable γ emission
	^99mTc-Human serum albumin	Nanocoll, Nanoalbumon, Nanotop	7-23	Registered in Europe; large clinical experience.
	^99mTc-Rhenium sulphide	Nanocis	8-68	Registered in Europe
	^99mTc-Sulphur colloid	TechneScan, TechneColl	50-1000	Registered in USA
	^99mTc-Antimony trisulphide	Lymph-Flo	2-23	Registered in Australia
	^99mTc-Calcium Phytate	Technephyte	150-200	Mostly used in Japan
	ICG-^99mTc-nanocolloid	N/A	700-900	Clinically introduced in 2009; it can be detected using nuclear medicine modalities and (near-infrared) fluorescence imaging
Receptor-based radiotracers	^99mTc-Tilmanocept	Lymphoseek	7 (mean)	Registered in USA and Europe
Receptor-based radiotracers	^99mTc- mannosyl neoglycoalbumin/ ^99mTc galactosyl neoglycoalbumin	N/A Galactoscint	9	Commercially available in Japan
Other	^99mTc-Isosulfan blue	N/A	639 nm	Radiolabelled dye; only preclinical experience