Table III.
Performance of candidate metabolites and blood markers for predicting GC.
| Variable | AUC (95%CI) | Youden index | Cut-off | Sensitivity, % | Specificity, % | Accuracy, % | PPV, % | NPV, % | P-value |
|---|---|---|---|---|---|---|---|---|---|
| GC vs. Pre | |||||||||
| miR-650 | 0.665 (0.586–0.744) | 0.2267 | 1.06 | 52.2 | 74.4 | 63.3 | 24.04 | 68.51 | 0.0001 |
| CA211 | 0.708 (0.608–0.807) | 0.4393 | 3.06 | 71.4 | 72.5 | 71.8 | 12 | 30.60 | 0.0004 |
| Model | 0.767 (0.678–0.857) | 0.5214 | 0.671 | 57.1 | 95 | 71.8 | 3 | 39.40 | <0.0001 |
| GC vs. NC | |||||||||
| miR-650 | 0.700 (0.613–0.788) | 0.5556 | 1.98 | 62.2 | 93.3 | 72.5 | 4.01 | 43.21 | 0.0001 |
| CA211 | 0.866 (0.785–0.947) | 0.8286 | 2.20 | 87.3 | 95.6 | 90.7 | 2.98 | 48.39 | <0.0001 |
| Model | 0.887 (0.818–0.956) | 0.8032 | 0.49 | 82.5 | 97.7 | 88.8 | 1.99 | 47.99 | <0.0001 |
GC, gastric carcinoma; AUC, area under the curve; CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value; Pre, precancerous lesions; NC, normal control; miR, microRNA; CA211, carbohydrate antigen 211.