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. 2020 Sep 15;8:100052. doi: 10.1016/j.ynpai.2020.100052

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© 2020 Published by Elsevier Inc.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4 — Interaction of chronic inflammatory pain and binge alcohol withdrawal on ERK phosphorylation. Binge alcohol exposure and withdrawal increased ERK phosphorylation in control but not CFA-treated rats in the (A) dorsomedial PFC, (B) ventromedial PFC, and (C) anterior cingulate cortex. (D) There was a significant interaction for CFA treatment and acute alcohol withdrawal on pERK in the insula, but no significant differences between groups. (E) pERK in the central amygdala was not significantly altered by CFA treatment or acute alcohol withdrawal. (F) Representative Western blots of pERK and total ERK in the anterior cingulate cortex. Data were analyzed using 2-way ANOVA and Tukey’s post hoc tests. Data are represented as mean ± SEM. Saline control + saline, solid white (n = 9); Saline control + acute alcohol WD, white striped (n = 11); CFA + saline, solid red (n = 9); CFA + acute alcohol WD, red striped (n = 9). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)