Table 4.

Results of the multiple binary regression analysis of clinical outcomes associated with adverse childhood experiences and polygenic risk score (categorical variables).

Variables	Coefficient	SE	df	p
History of psychotic featuresa
Number of ACE (CLES score)	0.056	0.042	1	0.18
BD–PRS	−0.11	0.077	1	0.15
Interaction	0.067	0.04	1	0.098
History of mixed symptomsa
Number of ACE (CLES score)	0.068	0.039	1	0.085
BD–PRS	−0.0008	0.074	1	0.91
Interaction	−0.006	0.041	1	0.89
History of suicide attemptsa
Number of ACE (CLES score)	0.18	0.039	1	<0001*
BD–PRS	−0.04	0.072	1	0.58
Interaction	−0.026	0.041	1	0.52
Presence of worsening in life functioninga
Number of ACE (CLES score)	0.26	0.062	1	<0.001*
BD–PRS	−0.15	0.094	1	0.12
Interaction	0.055	0.065	1	0.40
Presence of substance misusea
Number of ACE (CLES score)	0.13	0.04	1	<0.001*
BD–PRS	0.027	0.073	1	0.72
Interaction	−0.033	0.042	1	0.43

CLES childhood life events scale, ACE adverse childhood experience, PRS polygenic risk score, BD bipolar disorder.

^aAge at inclusion, age at onset, and sex were included as covariates in the analyses for all clinical outcomes.

^*P < 0.001.