Table 5.

Clinicopathologic characteristics of primary HHV8-negative EBL compared with clinical series of PEL

Characteristic	Primary HHV8-negative EBL (current study), n = 64	PEL65-67
HHV8 status	Negative	Positive
HIV infection	Negative	Positive
Median age, y	77	4466
Male	63%	>95%66
Site of involvement	Single site (59%)	Single site
	Multiple sites (41%)
Extracavitary involvement	No	Some
Pan B-cell markers (CD19, CD20, CD79a)	Positive	Negative
Plasma cell–related markers (CD138)	Usually negative (CD138 positive; 12%)	Positive
Prognosis	Favorable	Poor
	(2-y OS 84.7%)	(1-y OS 30%67)