Table 1.
Demographic and clinical characteristics of patients with and without major bleeding events
| Characteristic | Bleeding event (n = 89) | No bleeding event (n = 167) | P |
|---|---|---|---|
| Age, median (range), y | 65 (19-86) | 67 (24-92) | .373 |
| Race, n (%) | .140 | ||
| White | 72 (80.9) | 113 (67.8) | |
| Hispanic | 1 (1.1) | 2 (1.2) | |
| African American | 14 (15.7) | 48 (28.7) | |
| Asian | 2 (2.3) | 4 (2.4) | |
| ICU, n (%) | 66 (74.2) | 68 (40.7) | <.001 |
| Primary service, n (%) | .022 | ||
| Surgical | 56 (62.9) | 80 (47.9) | |
| Medical | 33 (37.1) | 87 (52.1) | |
| Sepsis, n (%)* | 37 (41.6) | 33 (19.8) | <.001 |
| Platelet count on day of blood sample collection, median (range), ×109/L† | 54.5 (8-200) | 79 (13-422) | .0004 |
| Serotonin release assay, n (%) | .863 | ||
| Positive | 10 (11.2) | 15 (8.9) | |
| Indeterminate | 1 (1.1) | 1 (0.6) | |
| Negative | 77 (86.5) | 150 (89.8) | |
| Missing | 1 (1.1) | 1 (0.6) | |
| PF4/H ELISA OD, n (%) | .749 | ||
| <0.4 | 63 (70.8) | 117 (70.1) | |
| 0.4-1.0 | 7 (7.9) | 16 (9.6) | |
| 1.0-2.0 | 7 (7.9) | 17 (10.2) | |
| >2.0 | 12 (13.5) | 16 (9.6) | |
| Missing | 0 (0) | 2 (1.2) | |
| HIT status, n (%) | .509 | ||
| Positive | 15 (16.9) | 23 (13.8) | |
| Negative | 74 (83.5) | 144 (86.2) |
ELISA, enzyme-linked immunosorbent assay; OP, optical density; PF4/H, platelet factor 4/heparin.
*
International Classification of Diseases, Ninth Revision, code for sepsis during admission that sGPVI was drawn.
†
Platelet count on day of blood sample collection (first count of day). Nine patients were missing a platelet count on day of blood sample collection.