Table 2.

Univariate and Multivariate Cox Regression Models to Identify Predictors for All-Cause Mortality in All Patients

Variable	Univariate Analysis			Multivariate Analysisa			Multivariate Analysisb
	HR	95% CI	P Value	HR	95% CI	P Value	HR	95% CI	P Value
Age	1.04	1.04–1.05	< 0.001	1.04	1.03–1.06	< 0.001	1.04	1.03–1.06	< 0.001
Female	0.54	0.44–0.68	< 0.001	0.73	0.52–1.04	0.09	0.77	0.53–1.12	0.18
CRT-D	0.71	0.56–0.91	0.007	0.72	0.47–1.12	0.14	0.74	0.45–1.22	0.23
Hypertension	0.97	0.83–1.14	0.73
Diabetes mellitus	1.49	1.26–1.76	< 0.001	1.77	1.35–2.31	< 0.001	1.84	1.35–2.49	< 0.001
Chronic kidney disease	2.46	2.09–2.89	< 0.001	1.47	1.12–1.93	0.006	1.45	1.07–1.98	0.02
Hyperlipidemia	0.99	0.85–1.16	0.94
Atrial fibrillation	1.33	1.13–1.55	< 0.001	1.18	0.91–1.53	0.20	1.07	0.79–1.43	0.67
ICM	2.02	1.71–2.38	< 0.001	1.14	0.86–1.50	0.36	1.15	0.856–1.57	0.37
LBBB	0.70	0.60–0.83	< 0.001	0.75	0.58–0.97	0.03	0.78	0.58–1.05	0.11
QRS duration	1.00	0.99–1.00	0.63
NYHA functional class	1.95	1.66–2.30	< 0.001	1.30	1.01–1.68	0.05	1.24	0.93–1.65	0.14
LVEF	0.99	0.98–1.00	0.064	0.98	0.96–1.00	0.03	0.98	0.96–1.00	0.10
TRT	1.38	1.14–1.67	0.001	1.20	0.71–2.04	0.50	1.43	1.02–2.02	0.04
Amiodarone	1.33	1.09–1.61	0.005	1.20	0.87–1.66	0.27	1.25	0.89–1.76	0.20
Statin	1.05	0.90–1.23	0.54
Digoxin	1.31	1.12–1.54	0.001	1.42	1.10–1.85	0.008	1.46	1.09–1.95	0.01
b-Blocker	0.90	0.71–1.15	0.41
ACEI/ARB	0.67	0.55–0.81	< 0.001	0.86	0.61–1.23	0.41	0.76	0.52–1.11	0.16
Aldactone	1.00	0.84–1.18	0.96
Furosemide	1.36	1.14–1.64	0.001	1.26	0.93–1.71	0.14	1.3	0.91–1.86	0.15
CRT response	0.41	0.32–0.52	< 0.001	0.42	0.32–0.54	< 0.001	0.45	0.33–0.60	< 0.001
Hypothyroidism	1.37	1.15–1.62	< 0.001	1.16	0.72–1.89	0.54	–	–	–
TSH per 5 mIU/L	1.41	1.29–1.55	< 0.001	–	–	–	0.94	0.74–1.19	0.60

^a Multivariate analysis including Hypothyroidism. ^b Multivariate analysis including TSH value. Abbreviations as in Table 1. TSH thyroid-stimulating hormone