Table 4.

Univariate and Multivariate Cox Regression Models to Identify Predictors for Appropriate ICD Therapy in Patients with Hypothyroidism

Variable	Univariate Analysis			Multivariate Analysis
	HR	95% CI	P Value	HR	95% CI	P Value
Age	0.99	0.97–1.01	0.42
Female	0.33	0.17–0.64	0.001	1.59	0.66–3.86	0.30
Primary prevention	0.46	0.28–0.74	0.002	0.15	0.02–1.21	0.07
Hypertension	0.85	0.53–1.38	0.52
Diabetes mellitus	0.79	0.45–1.38	0.41
Chronic kidney disease	1.90	1.16–3.11	0.01	1.81	0.95–3.48	0.07
Hyperlipidemia	0.75	0.47–1.22	0.25
Atrial fibrillation	1.18	0.74–1.89	0.48
ICM	1.60	0.98–2.59	0.06	0.99	0.51–1.95	0.98
LBBB	0.74	0.46–1.19	0.22
QRS duration	1.00	0.99–1.01	0.78
NYHA functional class	1.31	0.80–2.17	0.29
LVEF	0.99	0.95–1.03	0.55
TRT	0.74	0.45–1.23	0.25
amiodarone	1.79	1.10–2.89	0.02	0.36	0.05–2.81	0.33
Statin	1.14	0.71–1.83	0.57
Digoxin	1.03	0.64–1.65	0.91
b-Blocker	0.87	0.45–1.65	0.66
ACEI/ARB	0.78	0.45–1.36	0.39
Aldactone	0.68	0.39–1.17	0.16
Furosemide	1.23	0.71–2.11	0.46
CRT Response	0.44	0.24–0.80	0.007	0.58	0.31–1.12	0.11
TSH per 5 mIU/L	1.35	1.12–1.63	0.002	1.44	1.13–1.84	0.004

Abbreviations as in Table 1. TSH thyroid-stimulating hormone