Table 6.

Linear regression analysis with DNA methylation (DNAm) as the dependent variable and nutrition components, physical activity, or analytical parameters as independent variables and corrected for BMI

Nutrition
DNAm	BMI		Energy intake		Total carbohydrates		Total protein
Baseline	ß	p	ß	p	ß	p	ß	p
LPL (R = 0.46; R2 = 0.21)			− 0.03 (0.06 to − 0.04)	0.03	0.14 (0.02–0.253)	0.02	0.12 (0.01–0.23)	0.04
LEP (R = 0.34; R2 = 0.11)	− 0.50 (− 0.92 to − 0.08)	0.02
	MUFA		PUFA		Adherence to the MedDiet
	ß	p	ß	p	ß	p
LPL (R = 0.46; R2 = 0.21)	0.35 (0.09–0.61)	0.01	0.29 (0.05–0.53)	0.02	0.28 (0.02–0.53)	0.03
Physical activity
DNAm	Light activity		Moderate activity		Vigorous activity
Baseline	ß	p	ß	p	ß		p
SREBF (R = 0.44; R2 = 0.19)			− 0.43 (− 0.74 to − 0.11)	0.01
LEP (R = 0.35; R2 = 0.13)			0.13 (0.002–0.26)	0.05	− 0.62 (− 1.23 to − 0.001)		0.05
DNAm	Light activity		Moderate activity		Vigorous activity
12 m	ß	p	ß	p	ß		p
RXRa (R = 0.39; R2 = 0.15)	− 0.01 (− 0.02 to − 0.003)	0.01			− 0.11 (− 0.21 to − 0.01)		0.03
LEP (R = 0.35; R2 = 0.13)	− 0.02 (− 0.03 to − 0.003)	0.02
Analytical parameters
DNAm	Glc		HOMA-IR		hsPCR		Resistin
Baseline	ß	p	ß	p	ß	p	ß	p
LPL (R = 0.47; R2 = 0.23)					− 0.22 (− 0.39 to − 0.05)	0.01	0.20 (0.02–0.38)	0.03
RXR (R = 0.52; R2 = 0.27)					− 0.48 (− 0.91 to − 0.06)	0.03
SREBF (R = 0.51; R2 = 0.26)	0.71 (0.27–1.16)	0.002	2.16 (0.65–3.66)	0.01	2.16 (0.65–3.66)	0.01
DNAm	Glc		Insulin		HOMA-IR		cHDL
12 m	ß	p	ß	p	ß	p	ß	p
LXR (R = 0.52; R2 = 0.27)	− 0.08 (− 0.15 to − 0.01)	0.02			1.90 (0.20–3.60)	0.03
SCD (R = 0.75; R2 = 0.57)			0.25 (0.05-0.45)	0.01	− 1.01 (− 1.96 to − 0.07)	0.03	− 0.02 (− 0.03 to − 0.004)	0.01
	Resistin		IL-6		TNF-a
	ß	p	ß	p	ß	p
SCD (R = 0.75; R2 = 0.57)	− 0.04 (− 0.07 to − 0.01)	0.01	− 0.03 (− 0.04 to − 0.01)	0.001	0.05 (0.01–0.1)	0.02