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. 2020 Sep 23;10:113. doi: 10.1186/s13578-020-00472-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — NRP2 expression is positively correlated with PNET vascularity. a Heatmap summarizing the angiogenesis process signature (GSE73514) in metastatic-like primary (MLP) tumor and islet tumor (IT) samples. b Top: Comparison of NRP2 mRNA expression between the MLP and IT groups. Bottom: GSEA mountain plot showing a strong association between the MLP and IT groups. The data are presented as the means ± SD. *P ≤ 0.05 by Student’s t test. C, Representative expression of CD31, VEGFR2 and NRP2 in non-small-cell lung cancer (NSCLC), colorectal cancer (CRC) and pancreatic neuroendocrine tumor (PNET) specimens according to immunohistochemistry assays. d Correlation histograms of CD31, VEGFR2 and NRP2 expression in NSCLC, CRC and PNET specimens according to immunohistochemistry. Each number on the horizontal axis represents one specimen from the patients. The bars in the histograms show the mean percentage of positively staining cells under 5 randomly selected microscopic fields (20x). The Spearman R value and P value in the figures reflect the correlations of NRP2 and CD31 expression