Fig. 6.

Downregulation of NRP2 suppresses PNET angiogenesis and tumor growth in vivo and correlates with increased survival in patients. a The xenograft experiments in vivo with the mouse model with BON cells. After mice were injected with anti-NRP2 antibody or PBS intraperitoneally, the xenografts were dissected. b H&E staining was performed to determine the number of vessels in the xenograft tumors. The vascular number was calculated as the mean counts of vessels in 5 fields under 20 × magnification. ***P ≤ 0.001 by Student’s t test. c Tumor sizes were measured every other day after injection with PBS or NRP2 antibody. d Survival curve of PNET patients in the high and low NRP2 expression groups