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Kinetic parameters of mTrxR enzymes with Trx as substrate.
| Enzyme | kcat (min−1) | KM (μM) | kcat/KM (min−1 M−1) |
kcat/KM(mutant) /kcat/KM(WT) |
|---|---|---|---|---|
| mTrxR-CUG | 1770 ± 60 | 42 ± 4.4 | 4.2 x107 | – |
| mTrxR-C(αMe)UG | 15 ± 0.76 | 26 ± 4.8 | 5.8 x105 | 0.0138 |
| mTrxRΔ3 a | NA | NA | NA | – |
The truncated enzyme ends at glycine 487 and is missing the C-terminal tripeptide.
