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. 2020 Sep 15;12(9):942–956. doi: 10.4251/wjgo.v12.i9.942

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Different mechanisms of 5-fluorouracil action. 5-Fluorouracil (5_FU) and its derivative active metabolites exert their antitumor function at the levels of enzyme thymidylate synthase, DNA and RNA, leading to DNA and RNA damage and cell death. TS: Thymidylate synthase; FdUMP: Fluorodeoxyuridine’ monophosphate; FdUDP: Fluorodeoxyuridine diphosphate; FdUTP: Fluorodeoxyuridine triphosphate; FUMP: Fluorouridine monophosphate; FUDP: Fluorouridine diphosphate; FUTP: Fluorouridine triphosphate; CH2THF: 5,10-methylenetetrahydrofolate; dTTP: Deoxythymidine triphosphate; dUMP: Deoxyuridine monophosphate.