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. 2020 Sep 23;39:200. doi: 10.1186/s13046-020-01708-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — TMPRSS2 gene association with MYC signature and immune signature in HNSCC patients. a Box-plot analysis representing TMPRSS2 gene expression levels in tumoral HNSCC TCGA samples according to low or high expression values of MYC gene. b Box-plot analysis representing TMPRSS2 gene expression levels in tumoral HNSCC TCGA samples according to low or high expression values of 22-gene MYC signature. c Box-plot analysis representing TMPRSS2 gene expression levels in tumoral HNSCC TCGA samples according to low or high expression values of 17-gene immune signature. d-e qRT-PCR analysis of HPRT1 (d) and CSTF2 (e) expression levels in Cal-27 and Detroit-562 cell lines upon depletion of mutant p53 (sip53) or MYC (siMYC) compared to scramble control cells (value = 1). (f, g) qRT-PCR analysis of IL-10 (f) and IFNγ (g) expression levels in Cal-27 and Detroit-562 cell lines upon depletion of mutant p53 (sip53) or MYC (siMYC) compared to scramble control cells (value = 1). *p-value < 0.05