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. 2020 Sep 23;39:200. doi: 10.1186/s13046-020-01708-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — TMPRSS2 gene methylation status in normal and tumoral samples of HNSCC and lung cancer patients. a DNA methylation profile of TMPRSS2 gene in normal (blue line) and tumoral (red line) samples of HNSCC TCGA patients. b Box-plot analysis representing TMPRSS2 gene expression levels in non-tumorous (N) and tumor (T) tissues from the lung adenocarcinoma (LUAD) TCGA dataset. c DNA methylation profile of TMPRSS2 gene in normal (blue line) and tumoral (red line) samples of LUAD TCGA patients. d Box-plot analysis representing TMPRSS2 gene expression levels in non-tumorous (N) and tumor (T) tissues from the lung squamous cell carcinoma (LUSC) TCGA dataset. e DNA methylation profile of TMPRSS2 gene in normal (blue line) and tumoral (red line) samples of LUAD TCGA patients. DNA methylation profile has been performed by using Wanderer software. Beta values (β) are the estimate of methylation level using the ratio of intensities between methylated and unmethylated alleles. β values are between 0 and 1, with 0 being unmethylated and 1 fully methylated. The tool provides the detailed individual beta values of all the HumanMethylation450 probes inside or in the vicinity of the gene. Probes for the CpG island are indicated in green. Dotted red line indicates the threshold β value of 0.5