Table 1.
TMPRSS2 gene association with immune signature, MYC and MYC signature, HPV status and P53 mutation in HNSCC patients. Linear univariate and multivariate regression models were built from TCGA HNSCC patients considering TMPRSS2 as outcome variable. In the table is indicated the percentage of variance explained (R2) and the total p-value of the multivariate model
| univariate | |||||
| VAR | OR[CI95%] | p-value | beta | R2 | |
| HPV | 15.77 [7.69–32.36] | 2.74E-13 | 2.76 | 0.11 | |
| mutp53 | 0.21 [0.11–0.38] | 6.98E-07 | −1.57 | 0.05 | |
| signatureIMMUNO | 2.15 [1.21–3.83] | 9.36E-03 | 0.77 | 0.01 | |
| signatureMYC | 0.23 [0.13–0.41] | 6.71E-07 | −1.45 | 0.05 | |
| MYC | 0.25 [0.14–0.45] | 3.05E-06 | −1.38 | 0.04 | |
| multivariate | |||||
| VAR | OR[CI95%] | p-value | beta | R2 | model p-value |
| HPV | 7.70 [3.46–17.14] | 7.83E-07 | 2.04 | 0.15 | 3.24E-15 |
| mutp53 | 0.54 [0.28–1.05] | 7.07E-02 | −0.61 | ||
| signatureIMMUNO | 1.11 [0.63–1.95] | 7.07E-01 | 0.11 | ||
| signatureMYC | 0.41 [0.23–0.74] | 3.39E-03 | −0.88 | ||
| MYC | 0.53 [0.30–0.97] | 3.89E-02 | −0.62 | ||