Table 2.
KEGG enriched pathways evaluated from validated miRNA-target interactions (miRNet). Total number of genes included in each pathway and number of genes represented in each pathway (hits) with respective p-values are shown
| Pathway | Total | Hits | Pvalue |
|---|---|---|---|
| Cell cycle | 124 | 42 | 3.08E-15 |
| Small cell lung cancer | 80 | 22 | 9.85E-07 |
| Prostate cancer | 87 | 23 | 1.19E-06 |
| Pathways in cancer | 310 | 52 | 3.53E-06 |
| Focal adhesion | 200 | 38 | 4.18E-06 |
| p53 signaling pathway | 68 | 18 | 1.73E-05 |
| Pancreatic cancer | 69 | 18 | 2.15E-05 |
| HTLV-I infection | 199 | 36 | 2.37E-05 |
| Chronic myeloid leukemia | 73 | 18 | 4.90E-05 |
| Colorectal cancer | 49 | 14 | 6.03E-05 |
| Melanoma | 68 | 17 | 6.57E-05 |
| Adherens junction | 70 | 17 | 9.74E-05 |
| Non-small cell lung cancer | 52 | 14 | 1.23E-04 |
| Neurotrophin signaling pathway | 123 | 23 | 4.43E-04 |
| Glioma | 65 | 15 | 4.53E-04 |
| One carbon pool by folate | 19 | 7 | 8.40E-04 |
| Toxoplasmosis | 93 | 18 | 1.21E-03 |
| Fanconi anemia pathway | 39 | 10 | 1.72E-03 |
| Renal cell carcinoma | 60 | 13 | 1.99E-03 |
| Selenocompound metabolism | 12 | 5 | 2.59E-03 |
| Oocyte meiosis | 108 | 19 | 2.87E-03 |
| Bladder cancer | 29 | 8 | 3.02E-03 |
| Acute myeloid leukemia | 57 | 12 | 3.78E-03 |
| Progesterone-mediated oocyte maturation | 80 | 15 | 4.17E-03 |
| Glyoxylate and dicarboxylate metabolism | 19 | 6 | 4.85E-03 |
| Regulation of actin cytoskeleton | 182 | 27 | 5.39E-03 |
| Pyrimidine metabolism | 101 | 17 | 7.41E-03 |
| ErbB signaling pathway | 87 | 15 | 9.27E-03 |
| Thyroid cancer | 28 | 7 | 9.75E-03 |
| MAPK signaling pathway | 265 | 35 | 1.08E-02 |
| Influenza A | 107 | 17 | 1.31E-02 |
| Endometrial cancer | 44 | 9 | 1.40E-02 |
| RNA transport | 126 | 19 | 1.54E-02 |
| Herpes simplex infection | 103 | 16 | 1.93E-02 |
| Protein processing in endoplasmic reticulum | 129 | 19 | 1.94E-02 |
| Glycine, serine and threonine metabolism | 33 | 7 | 2.39E-02 |
| Viral myocarditis | 26 | 6 | 2.41E-02 |
| Cysteine and methionine metabolism | 34 | 7 | 2.79E-02 |
| Jak-STAT signaling pathway | 99 | 15 | 2.83E-02 |
| mRNA surveillance pathway | 82 | 13 | 2.85E-02 |
| Epstein-Barr virus infection | 91 | 14 | 2.97E-02 |
| Valine, leucine and isoleucine degradation | 44 | 8 | 3.84E-02 |
| Pertussis | 52 | 9 | 3.85E-02 |
| mTOR signaling pathway | 45 | 8 | 4.32E-02 |
| Tight junction | 118 | 16 | 5.85E-02 |