Prevalence of underlying conditions among U.S. adults with and without COVID-19, overall and by age. Estimates for U.S. adults came from the 2017–2018 NHANES. Estimates for COVID-19 case subjects were calculated from CDC’s notifiable disease surveillance COVID-19 case reporting, as reported in Stokes et al. (4). Diabetes was defined as prior diagnosis or calibrated HbA1c ≥6.5% in the NHANES and as diabetes on the CDC’s COVID-19 case report form. COPD was defined as a prior diagnosis in the NHANES and as chronic lung disease on the CDC’s COVID-19 case report form. Cardiovascular disease was defined as self-reported history of coronary heart disease, heart failure, heart attack, stroke, or hypertension (mean blood pressure ≥130/≥80 mmHg or use of antihypertensive medication) in the NHANES and as hypertension or cardiovascular disease on the CDC’s COVID-19 case report form. Chronic kidney disease was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2 or an albumin-to-creatinine ratio ≥30 mg/g in the NHANES and as chronic renal disease on the CDC’s COVID-19 case report form.