Table 3.
The number of years (Δ) of age (A) or duration of T1D (B) that provides the same ratio of risk of outcomes (OR for CAN and HR for others) as does the mean updated HbA1c stratified by HbA1c levels <7.5%, ≥7.5% and <8.5%, and ≥8.5%
| Δ | LL | UL | z | |
|---|---|---|---|---|
| A. The additional years of age equivalent to a 1-percentage point increase in HbA1c | ||||
| Reduced eGFR | ||||
| Overall | 12.1 | 8.3 | 15.9 | 6.29 |
| HbA1c <7.5% | −0.7 | −5.3 | 4.0 | 0.28 |
| 7.5% ≤ HbA1c < 8.5% | 10.4 | 2.5 | 18.3 | 2.57 |
| HbA1c ≥8.5% | 25.3 | 8.6 | 42.0 | 2.98 |
| CAN | ||||
| Overall | 5.0 | 3.5 | 6.4 | 6.75 |
| HbA1c <7.5% | 1.2 | −2.7 | 5.2 | 0.61 |
| 7.5% ≤ HbA1c < 8.5% | 4.2 | −1.2 | 9.5 | 1.51 |
| HbA1c ≥8.5% | 6.2 | 3.1 | 9.3 | 3.95 |
| B. The additional years’ duration of T1D equivalent to a 1-percentage point increase in HbA1c | ||||
| PDR | ||||
| Overall | 6.4 | 5.3 | 7.4 | 11.62 |
| HbA1c <7.5% | 11.8 | 1.7 | 22.0 | 2.29 |
| 7.5% ≤ HbA1c < 8.5% | 10.4 | 4.8 | 16.1 | 3.59 |
| HbA1c ≥8.5% | 5.4 | 4.2 | 6.6 | 8.79 |
| CSME | ||||
| Overall | 7.1 | 5.4 | 8.8 | 8.03 |
| HbA1c <7.5% | 10.6 | 0.2 | 21.0 | 1.99 |
| 7.5% ≤ HbA1c < 8.5% | 17.2 | 6.9 | 27.6 | 3.26 |
| HbA1c ≥8.5% | 6.3 | 4.2 | 8.4 | 5.93 |
The z values correspond to a test of the null hypothesis ∆ = 0. Only results for outcomes with z-test values for interactions >2 in absolute value (or equivalently, a two-sided P value <0.046) for an interaction term between the mean updated HbA1c and age (A) and duration of T1D (B) are shown. HbA1c values of 7.5% and 8.5% correspond to 58 mmol/mol and 69 mmol/mol, respectively.
LL, lower limit for 95% CIs; UL, upper limit for 95% CIs.