Table 2.
Total (n = 500) | Stroke (n = 500) | Acute chest syndrome (n = 500) | Leg ulcers (n = 500) | Osteonecrosis (n = 500) | Cholelithiasis (n = 500) | Retinopathy (n = 366) | Total retinopathy (n = 366) | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No | Yes | No | Yes | No | Yes | No | Yes | No | Yes | No | Yes | |||
rs4696480 | 495 | 364 | ||||||||||||
AA | 164 | 131 | 33 | 87 | 77 | 135 | 29 | 136 | 28 | 57 | 107 | 74 | 55 | 129 |
AT | 280 | 249 | 31 | 179 | 101 | 247 | 33 | 233 | 47 | 145 | 135 | 120 | 80 | 200 |
TT | 51 | 48 | 3 | 30 | 21 | 45 | 6 | 39 | 12 | 27 | 24 | 20 | 15 | 35 |
rs4833095 | 470 | 344 | ||||||||||||
AA | 142 | 124 | 18 | 80 | 62 | 122 | 20 | 116 | 26 | 67 | 75 | 45 | 55 | 100 |
AG | 210 | 180 | 30 | 117 | 93 | 186 | 24 | 176 | 34 | 88 | 122 | 90 | 66 | 156 |
GG | 118 | 97 | 21 | 81 | 37 | 95 | 23 | 95 | 23 | 53 | 65 | 66 | 22 | 88 |
rs2246809 | 495 | 361 | ||||||||||||
AA | 34 | 30 | 4 | 26 | 8 | 30 | 4 | 27 | 7 | 16 | 18 | 19 | 5 | 24 |
AG | 197 | 177 | 20 | 115 | 82 | 178 | 19 | 162 | 35 | 101 | 96 | 91 | 57 | 148 |
GG | 264 | 218 | 46 | 155 | 109 | 218 | 46 | 218 | 46 | 111 | 153 | 103 | 86 | 189 |
rs9380142 | 487 | 354 | ||||||||||||
AA | 295 | 256 | 39 | 182 | 113 | 255 | 40 | 245 | 50 | 153 | 142 | 116 | 93 | 209 |
AG | 166 | 145 | 21 | 95 | 71 | 144 | 22 | 133 | 33 | 59 | 107 | 79 | 48 | 127 |
GG | 26 | 19 | 7 | 16 | 10 | 20 | 6 | 22 | 4 | 11 | 15 | 14 | 4 | 18 |
rs3804099 | 496 | 363 | ||||||||||||
CC | 176 | 159 | 17 | 104 | 72 | 157 | 19 | 144 | 32 | 93 | 83 | 73 | 68 | 141 |
CT | 222 | 192 | 30 | 127 | 95 | 192 | 30 | 183 | 39 | 95 | 127 | 99 | 60 | 159 |
TT | 98 | 75 | 23 | 65 | 33 | 78 | 20 | 80 | 18 | 39 | 59 | 43 | 20 | 63 |
rs5743810 | 497 | 363 | ||||||||||||
AA | 12 | 7 | 5 | 8 | 4 | 11 | 1 | 12 | 0 | 6 | 6 | 6 | 1 | 7 |
AG | 68 | 53 | 15 | 46 | 22 | 61 | 7 | 60 | 8 | 24 | 44 | 42 | 11 | 53 |
GG | 417 | 366 | 51 | 245 | 172 | 356 | 61 | 335 | 82 | 197 | 220 | 166 | 137 | 303 |
rs2617169 | 497 | 363 | ||||||||||||
AA | 12 | 12 | 0 | 9 | 3 | 10 | 2 | 10 | 2 | 7 | 5 | 7 | 1 | 8 |
AT | 144 | 131 | 13 | 86 | 58 | 130 | 14 | 122 | 22 | 73 | 71 | 70 | 37 | 107 |
TT | 341 | 283 | 58 | 202 | 139 | 288 | 53 | 276 | 65 | 148 | 193 | 138 | 110 | 248 |
rs2517523 | 484 | 356 | ||||||||||||
AA | 112 | 96 | 16 | 63 | 49 | 92 | 20 | 96 | 16 | 53 | 59 | 47 | 31 | 78 |
AG | 223 | 190 | 33 | 139 | 84 | 196 | 27 | 176 | 47 | 105 | 118 | 103 | 71 | 174 |
GG | 149 | 128 | 21 | 86 | 63 | 129 | 20 | 126 | 23 | 61 | 88 | 61 | 43 | 104 |
rs3804100 | 485 | 357 | ||||||||||||
CC | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
CT | 43 | 34 | 9 | 28 | 15 | 37 | 6 | 34 | 9 | 17 | 26 | 188 | 134 | 322 |
TT | 441 | 381 | 60 | 258 | 183 | 380 | 61 | 363 | 78 | 201 | 240 | 23 | 12 | 35 |
rs1049174 | 496 | 362 | ||||||||||||
CC | 77 | 53 | 24 | 44 | 33 | 64 | 13 | 65 | 12 | 22 | 55 | 34 | 12 | 46 |
CG | 182 | 156 | 26 | 110 | 72 | 158 | 24 | 154 | 28 | 83 | 99 | 89 | 58 | 147 |
GG | 237 | 216 | 21 | 144 | 93 | 205 | 32 | 188 | 49 | 123 | 114 | 90 | 79 | 169 |
rs2617170 | 499 | 366 | ||||||||||||
CC | 95 | 82 | 13 | 54 | 41 | 85 | 10 | 76 | 19 | 40 | 55 | 35 | 34 | 69 |
CT | 246 | 218 | 28 | 150 | 96 | 209 | 37 | 201 | 45 | 121 | 125 | 114 | 80 | 194 |
TT | 158 | 129 | 29 | 95 | 63 | 136 | 22 | 133 | 25 | 68 | 90 | 67 | 36 | 103 |
rs1051792 | 473 | 349 | ||||||||||||
AA | 195 | 162 | 33 | 123 | 72 | 169 | 26 | 159 | 36 | 93 | 102 | 81 | 61 | 142 |
AG | 169 | 146 | 23 | 91 | 78 | 149 | 20 | 143 | 26 | 76 | 93 | 73 | 56 | 129 |
GG | 109 | 94 | 15 | 63 | 46 | 88 | 21 | 86 | 23 | 38 | 71 | 49 | 29 | 78 |
rs11466653 | 496 | 365 | ||||||||||||
AA | 450 | 392 | 58 | 272 | 178 | 389 | 61 | 369 | 81 | 210 | 240 | 191 | 141 | 332 |
GA | 44 | 34 | 10 | 24 | 20 | 37 | 7 | 36 | 8 | 18 | 26 | 23 | 8 | 31 |
GG | 2 | 2 | 0 | 1 | 1 | 2 | 0 | 2 | 0 | 1 | 1 | 2 | 0 | 2 |
rs2255336 | 498 | 365 | ||||||||||||
CC | 165 | 128 | 37 | 102 | 63 | 138 | 27 | 140 | 25 | 60 | 105 | 77 | 40 | 117 |
CT | 232 | 208 | 24 | 130 | 102 | 202 | 30 | 186 | 46 | 116 | 116 | 99 | 78 | 177 |
TT | 101 | 92 | 9 | 66 | 35 | 89 | 12 | 83 | 18 | 53 | 48 | 40 | 31 | 71 |
rs2617171 | 485 | 356 | ||||||||||||
CC | 246 | 225 | 21 | 146 | 100 | 215 | 31 | 197 | 49 | 128 | 118 | 94 | 87 | 181 |
CG | 161 | 137 | 24 | 98 | 63 | 139 | 22 | 139 | 22 | 71 | 90 | 82 | 47 | 129 |
GG | 78 | 58 | 20 | 45 | 33 | 65 | 13 | 66 | 12 | 25 | 53 | 33 | 13 | 46 |
rs5742909 | 470 | 345 | ||||||||||||
CC | 434 | 376 | 58 | 251 | 183 | 371 | 63 | 353 | 81 | 191 | 243 | 177 | 144 | 321 |
CT | 35 | 25 | 10 | 24 | 11 | 30 | 5 | 34 | 1 | 13 | 22 | 21 | 2 | 23 |
TT | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
rs11096957 | 496 | 362 | ||||||||||||
GG | 129 | 115 | 14 | 71 | 58 | 108 | 21 | 105 | 24 | 61 | 68 | 57 | 41 | 98 |
GT | 253 | 216 | 37 | 159 | 94 | 220 | 33 | 207 | 46 | 116 | 137 | 108 | 70 | 178 |
TT | 114 | 95 | 19 | 67 | 47 | 100 | 14 | 94 | 20 | 52 | 62 | 49 | 37 | 86 |
rs2617160 | 496 | 364 | ||||||||||||
AA | 94 | 85 | 9 | 62 | 32 | 85 | 9 | 76 | 18 | 45 | 49 | 48 | 20 | 68 |
AT | 248 | 213 | 35 | 151 | 97 | 213 | 35 | 201 | 47 | 120 | 128 | 117 | 81 | 198 |
TT | 154 | 128 | 26 | 83 | 71 | 130 | 24 | 131 | 23 | 63 | 91 | 50 | 48 | 98 |
rs1983526 | 496 | 362 | ||||||||||||
CC | 26 | 19 | 7 | 12 | 14 | 23 | 3 | 23 | 3 | 9 | 17 | 9 | 6 | 15 |
CG | 155 | 126 | 29 | 98 | 57 | 128 | 27 | 129 | 26 | 65 | 90 | 74 | 43 | 117 |
GG | 315 | 280 | 35 | 186 | 129 | 276 | 39 | 256 | 59 | 154 | 161 | 131 | 99 | 230 |
rs231775 | 469 | 347 | ||||||||||||
AA | 177 | 157 | 20 | 106 | 71 | 153 | 24 | 151 | 26 | 82 | 95 | 74 | 58 | 132 |
AG | 221 | 182 | 39 | 128 | 93 | 189 | 32 | 172 | 49 | 93 | 128 | 105 | 61 | 166 |
GG | 71 | 63 | 8 | 40 | 31 | 59 | 12 | 62 | 9 | 31 | 40 | 23 | 26 | 49 |
For all SNPs, the total n is <500 because of missing genotyping data.